Indra Gupta, Ph.D.
Dr. Gupta’s laboratory is interested in the genetic regulation of kidney and urinary tract development using the mouse as a model system. Mouse development mirrors the stages that occur in the human and can be used in the study of kidney malformations such as renal dysplasia and urinary tract disorders like vesicoureteric reflux and obstructive uropathy. Please follow the link for further informaiton. PubMed listings
Dr. Indra Gupta obtained her MD at the University of Alberta in 1988 and completed her Pediatrics at McMaster University. Her subspecialty training in Pediatric Nephrology was at the Hospital for Sick Children in Toronto. She completed two research fellowships at the Hospital for Sick Children under the direction of Dr. Karl Skorecki and then Dr. Norman Rosenblum. Her laboratory has been funded by the March of Dimes, the CIHR, and the Kidney Foundation of Canada.
In most cases of pediatric endstage renal disease, the kidneys fail to develop normally in utero. In a significant proportion of these cases, urinary tract abnormalities such as ureteral obstruction and vesicoureteric reflux are also detected. The co-occurrence of kidney and urinary tract malformations is not surprising: both tissues originate from the same embryonic structure: the ureteric bud, an outgrowth from the mesonephric duct. The position where the ureteric bud arises is determined by transcription factors and signaling events that are relayed between the adjacent mesenchyme and the mesonephric duct. My laboratory is interested in understanding the molecular basis of kidney and urinary tract malformations in humans by using cell lines and mouse models to ask questions about the development of these two systems.
Tristan Alie (MSc)
Nicholas Haddad (MSc 2009)
Inga Murawski (PhD 2009)
I am currently looking for new graduate students.