Published in Nature Genetics 46, 438-443 (2014)
“Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is the most common undifferentiated type of ovarian cancer diagnosed in women below the age of 40. While it is rare, with only ~400 cases described in the English literature, it is a very aggressive disease, with 5-yr survival rates for early stage diagnoses at 33%. Prior to our publication, the histogenesis of the disease remained elusive, and publications discussing the histogenesis of SCCOHT were merely speculative. Our publication confirmed for the first time that SCCOHT is a monogenic disorder and that deleterious germline mutations in the chromatin remodelling gene SMARCA4 predispose to the development of SCCOHT. Our discovery provides women with a family history of early onset ovarian cancer with the option of being tested for germline mutations in SMARCA4, and provides patients with an answer as to why the cancer developed.”
Cette molécule qui nous déprime (Institut Douglas – Université McGill)
Que se passe-t-il dans le cerveau en cas de dépression?
En autopsiant des cerveaux, des chercheurs de l’Institut Douglas ont trouvé qu’une petite molécule, la miR-1202, était présente en moins grande quantité dans le cerveau des personnes dépressives que dans celui des personnes en bonne santé mentale. Ce «micro-ARN» régule l’expression de plusieurs gènes, dont celui du récepteur au glutamate, un neurotransmetteur qui exerce un effet stimulant sur le cerveau. L’équipe a aussi découvert que la miR-1202 est moins abondante dans le sang des personnes dépressives. Et ce n’est pas tout: le taux de miR-1202 augmente chez les patients qui répondent bien aux médicaments antidépresseurs. Ce marqueur constitue donc à la fois un indicateur de dépression et un indicateur de réponse au traitement, mais aussi une piste pour mettre au point de nouveaux médicaments contre la dépression.
Appointment of Dr. Gustavo Turecki as Chair of the Department of Psychiatry at McGill
It is with great pleasure that we announce the appointment of Dr. Gustavo Turecki as Chair of the Department of Psychiatry, Faculty of Medicine, McGill University, effective March 1, 2015. Dr. Turecki succeeds Dr. Mimi Israël, who led the department with great distinction since 2007. We take this opportunity to offer our sincere thanks to Dr. Israël for her outstanding leadership throughout her term, and we wish her continued success.
Dr. Turecki is Professor in the Department of Psychiatry at McGill, where he currently is Associate Chair of Research and Academic Affairs. He has been an Attending Psychiatrist at the Douglas Mental Health University Institute since 1999, and he is also Director of the McGill Group for Suicide Studies, as well as head of its Depressive Disorders Program and Co-Director of the Douglas Bell-Canada Brain Bank. In addition, he is the Director of the Fonds de recherche du Québec – Santé (FRQS) funded provincial network on suicide and mood disorders.
Dr. Turecki studied at Escola Paulista de Medicina in Brazil, earning an MD, as well as a Masters of Science in Psychiatric Epidemiology/Genetics. He completed his Psychiatry residency at São Paulo General Hospital in Brazil, and he obtained a PhD in Neuroscience (Genetics) at McGill. He is a Fellow of several scientific and professional organizations, has served as President of the International Academy of Suicide Research, and currently sits on Council for the American Foundation for Suicide Prevention (AFSP) and the International College of Neuropsychopharmacology.
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